Secrets of THC, CBD and Terpene in Medical Marijuana
There are more than 85 active cannabinoids in the marijuana plant. The three most important bioactive components are THC, CBD and Terpenes.
THC was first discovered in 1964 but it was not until 1988 that Dr Allyn Howell of Wake forest University found the sites where THC attached itself to specific were mainly in the brain, central and peripheral nervous system.
These unique cannabinoid only receptors, when activated, were found responsible for changes in memory, movement and thought.
These receptors are part of the endocanabinoid system (ECS). This endogenous system is found in all vertebrates.
THC activates behavior and cognitive changes. It’s psychoactive and it makes you feel different.
In addition to cognitive changes, THC activates the immune system, reduces inflammation. It has 20 times the effect of aspirin and is antispasmodic, anti-cancer cell growth in brain cancer, releases hunger hormones and increases your metabolism. It can also sedate and makes you sleepy depending on dosage.
Humans also naturally produce a THC like substance, it’s called, ANANDAMIDE. In our body this substance has been shown to cause forgetfulness. It cleans out our memory banks of unimportant and unpleasant memories. This property can be useful in the treatment of PTSD disorder.
One main difference with plant THC is that the human type lasts a very short time, while the plant is long lasting (several days). This is a huge clinical difference.
While we don’t produce THC, it actually taps into the ESC system we already have.
THC synthetics are already in our pharmacy shelves (MARINOL) approved for the treatment of nausea in cancer patients. And (SATIVEX) approved for multiple sclerosis.
The most amazing property of THC has been found in its effect against cancer cells. Studies show that THC causes tumor cells to actually auto digest themselves, reducing tumor size.
Another important effect of THC is potent anti-inflammatory effect.
Inflammation is the main negative effect causing degenerative diseases, including all autoimmune diseases and neurodegenerative disorders.
Studied diseases that respond to THC include: Alzheimer, arthritis, ADHD, autism, PTSD, Glaucoma, Hepatitis, Migraines, Multiple sclerosis, Lupus, Parkinsonism, chronic pain, and Neuropathic pain syndromes.
Great strides and discoveries are being made worldwide in the medical use of medical marijuana.
This secondary cannabinoid is not psychoactive; it actually serves to balance the psychoactive effect of THC. It acts to reduce this effect. Its main effect is anti-inflammatory and antispasmodic.
The ratio of THC-CBD in the original marijuana plant was actually 1:1. Currently 95% of plants are hybrids. Man has bred this plant primarily for its THC effect.
CBD binds to different receptors and has a lot of beneficial effects on its own. While the THC binds primarily in the brain; CBD binds primarily to receptors in the abdomen and organs. Its largest concentration is in the spleen. CBD and THC are actually synergistic, more effective together than separately.
CBD also helps to increase our own Anandamide production by inhibiting the enzyme (FAAH) that breaks it down.
Because of its THC opposing effect, different strains of marijuana can cause a variety of effects. Our own body’s ability to produce and process Anandamide will also impact our effect and results of the experience.
Most doctors prefer treatments with CBD because it can’t make you high and is preferable for children’s use.
While TCH can make some people paranoid, CBD can have the opposite effect.
Studies show that different CBD strains together with low THC promote sleep.
A pharmaceutical form of CBD Epidiolex has recently been cleared by the FDA for severe epilepsy.
CBD binds with TRPV-1 receptor that by reducing pain perception and inflammation is effective against pain, especially neuropathic pain.
Cancer and Osteoporosis:
CBD is antagonic to GPR55; this receptor increases cancer cell proliferation and bone loss (osteoporosis) (according to recent studies, 2010.
Antipsychotic, reduces Dopamine levels.
CBD degrades Amyloidal plaques.
CBD improves insulin sensitivity, lipid uptake, energy homeostasis.
Further studies will be able to individualize the best strains and CBD –THC dosages for your individual need.
TERPS are natural aromatic resin and oils present in plants and some insects.
TERPS defend the plant and animal kingdom against parasites, microorganisms, predators. They also alert to the presence of food and mates as well as enemies.
Only a small amount of TERPENES have actually been investigated. Recent studies show that Terpenes alter the properties of cannabis and may be the main reason behind the different cannabis medical effects. There are 11 main TERP molecules found in the marijuana plant. They are non-psychogenic. Some TERPS can also inhibit the psychogenic effect of THC allowing the patient to take a larger medicinal dose without unpleasant effects.
Some patients have unpleasant symptoms of paranoia when consuming marijuana. Studies show that chewing or smelling the aroma of black peppercorns will have an immediate effect and blocks this unpleasant side effect. Peppers contain Myrcene, a Terpene.
Medicinal effects of TERPS as neurotransmitters:
Enhancing norepinephrine, similar to (Tricyclides) antidepressant, Increasing Dopamine, (Levodopa) anti-Parkinsonism, Increasing GABA (Benzos) anxiolytic, anticonvulsivant Serotonin Uptake Inhibitor, (Prozac), antidepressants
Aroma as a way to detect effect of TERPS:
Musky smell (Myrcene) generally has a relaxing effect, sedative, muscle relaxant.
Pine smell (Pirene, Terpineol) generally increases mental alertness and memory.
Lemon smell (Limonene) mood elevation.
Sweet berry smell sedating (Indica) Earthy and Pine stimulating (Sativa)
Our doctor has been a physician for four decades with experience as a family practice doctor, preventative physician, surgeon, and emergency room doctor.
Get pain relief treatment from an experienced physician at Florijuana Medical Center.
Schedule a consultation with us today and find out if medical marijuana treatment is right for you. Our private practice is happy to accept new patients. We are also bilingual - our doctor and staff speak fluent Spanish.